18.Synthesis of Spirocyclic Piperidines via Radical Hydroarylation

Racheal M. Spurlin,* Amber L. Harris,* Cameron J. Pratt, and Nathan T. Jui Synlett. 2021, 32 (02), 211-214

DOI: 10.1055/a-1315-1014

17.Development of a new class of liver receptor homolog-1 (LRH-1) agonist by photoredox conjugate addition

Jeffery L. Cornelison,* Michael L. Cato,* Alyssa M. Johnson, Emma H. D'Agostino, Diana Melchers, Anamika B. Patel, Suzanne G. Mays, Rene Houman, Eric A. Ortlund, and Nathan T. Jui Bioorg. Med. Chem. Lett. 2020, 30 (16), 127293

DOI: 10.1016/j.bmcl.2020.127293

16. Hydroarylation of Arenes via Reductive Radical-Polar Crossover 

Autumn R. Flynn,* Kelly A. McDaniel,* Meredith E. Hughes, David B. Vogt, and Nathan T. Jui J. Am. Chem. Soc. 2020, 142 (20), 9163-9168 DOI: 10.1021/jacs0c03926

15. Development of a Versatile and Sensitive Direct Ligand Binding Assay for Human NR5A Nuclear Receptors 

Emma H. D'Agostino, Autumn R. Flynn, Jeffery L. Cornelison,  Suzanne G. Mays, Anamika Patel, Nathan T. Jui, and Eric A. Ortlund. ACS Med. Chem. Lett. 2020, 11 (3), 365-370. DOI: 10.1021/acsmedchemlett.9b00442

Part of the "Women in Medicinal Chemistry" Cluster

14. Development of the First Low-Nanomolar Liver Receptor Homolog-1 Agonist Through Structure-Guided Design

Suzanne G. Mays, Autumn R. Flynn, Jeffery L. Cornelison,  C. Denise Okafor, Hongtao Wang, Guohui Wang, Xiangsheng Huang, Heather N. Donaldson, Elizabeth J. Millings, Rohini Polavarapu, David Moore, John Calvert, Nathan T. Jui, and Eric A. Ortlund. J. Med. Chem. 2019, 62 (24), 11022-11034. DOI: 10.1021/acs.jmedchem.9b00753

13. Radical alpha-C-H Cyclobutylation of Aniline Derivatives

Cameron J. Pratt, Max D. King, and Nathan T. Jui, Synlett, 201930, A–D

J.A.C.S. #1 Most Read article in August 2019 

J.A.C.S. #14 Most Read in 2019 

12. Selective C-F Functionalization of Unactivated Trifluoromethylarenes

11. Intermolecular Reactions of Pyridyl Radicals with Olefins via Photoredox Catalysis

10. Catalytic Strategy for Regioselective Arylethylamine Synthesis

9. Radical Hydroarylation of Functionalized Olefins and Mechanistic Investigation of Photocatalytic Pyridyl Radical Reactions

8. Development of Hybrid Phospholipid Mimics as Effective Agonists for Liver Receptor Homolog-1

Autumn R. Flynn,  Suzanne G. Mays, Eric A. Ortlund, and Nathan T. Jui,  ACS Med. Chem. Lett. 2018, 9 (10), pp 1051–1056

7. Aminoalkyl Radicals as Powerful Intermediates for the Synthesis of Unnatural Amino Acids and Peptides

R. Adam Aycock,* Cameron J. Pratt,* and Nathan T. Jui,  ACS Catal., 2018, 8, 9115–9119

6. Catalytic Defluoroalkylation of Trifluoromethylaromatics with Unactivated Alkenes

5. A Practical and Scalable System for Heteroaryl Amino Acid Synthesis

R. Adam Aycock, David B. Vogt, and Nathan T. Jui, Chem. Sci., 2017, 8, 7998-8003 

J. Dihydropyrimidine-thiones and Clioquinol Synergize to Target  Beta-Amyloid Cellular Pathologies Through a Metal-Dependent Mechanism

Daniel F Tardiff, Lauren E. Brown, Xiaohui Yan, Richard Trilles, Nathan T Jui, M. Inmaculada Barrasa, Kim A Caldwell, Guy A Caldwell, Scott E. Schaus, and Susan Lindquist, ACS Chem. Neurosci. 2017

4. Anti-Markovnikov Hydroarylation of Unactivated Olefins using Pyridyl Radical Intermediates

Boyington, A. J.; Riu, M.-L.; Jui, N. T. J. Am. Chem. Soc., 2017, 139 (19),  6582–6585

3. Screening and Functional Profiling of Small-Molecule HIV-1 Entry and Fusion Inhibitors

Giroud Charline, Du Yuhong, Marin Mariana, Min Qui, Jui Nathan T., Fu Haian, and Melikyan Gregory B. Assay Drug Dev. Technol. March 2017, 15 (2), 53-63

2. A Mild Catalytic System for Radical Conjugate Addition of Nitrogen Heterocycles

Aycock, R. A.; Wang H.; Jui, N. T. Chem. Sci., 2017,8, 3121.

In the collection of: Chem. Sci. Most Downloaded Articles of 2017: Organic Chemistry

1. Crystal Structures of the Nuclear Receptor, Liver Receptor Homolog 1, Bound to Synthetic Agonists Reveal a Novel Mechanism of Activation

 Suzanne G. Mays; C. Denise Okafor; Richard J. Whitby; Devrishi Goswami; Jozef Stec; Autumn R. Flynn; Michael C. Dugan; Nathan T. Jui; Patrick R. Griffin; and Eric A. Ortlund. J. Biol. Chem. 2016291, 25281.

Cover Article, Issue 291, 2016

Recommended by F1000


I. Regioselective Synthesis of Benzimidazolones via Cascade C-N Coupling of Monosubstituted Ureas

Ernst, J. B.; Tay, N. E. S.; Jui, N. T.; Buchwald, S. L. Org. Lett201416, 3884.

H. Identification and Rescue of a-Synuclein Toxicity in Parkinson Patient-Derived Neurons

Chung, C. Y.; Khurana, V.; Auluck, P. K.; Tardiff, D. F.; Mazulli, J. R.; Soldner, F.; Baru, V.; Lou, Y.; Freyzon, Y.; Cho, S.; Mungenast, A. E.; Muffat, J.; Mitalopoa, M.; Pluth, M. D.; Jui, N. T.; Schüle, B.; Lippard, S. L.; Tsai, L.-H.; Krainc, D.; Buchwald, S. L.; Jaenisch, R.; Lindquist, S. Science 2013342, 983.

G. Yeast Reveal a "Druggable" RSP5/NEDD4 Network that Ameliorates a-Synuclein Toxicity in Neurons

Tardiff, D. F.; Jui, N. T.; Khurana, V.; Tambe, M. A.; Thompson, M. L.; Chung, C. Y. Kamadurai, H.; Kim, H.-T.; Lancaster, A. K.; Caldwell, K. A.; Caldwell, G. A.; Rochet, J.-C.; Buchwald, S. L.; Lindquist, S. Science 2013342, 979.

F. Cascade Palladium Catalysis:  A Predictable and Selectable Regiocontrolled Synthesis of N-Arylbenzimidazoles

 Jui, N. T.; Buchwald, S. L. Angew. Chem., Int. Ed201344, 11624.

E. Enantioselective Organo-SOMO Cycloadditions:  A Catalytic Approach to Complex Pyrrolidines from Olefins and Aldehydes

Jui, N. T.; Garber, J. A. O.; Finelli, F. G.; MacMillan, D. W. C. J. Am. Chem. Soc2012134, 11400.

D. Enantioselective Organo-SOMO Cascade Cycloadditions:  A Rapid Approach to Molecular Complexity from Simple Aldehydes and Olefins

Jui, N. T.; Lee, E. C. Y.; MacMillan, D. W. C.  J. Am. Chem. Soc. 2010132, 10015.

C. Enantioselective Organo-Singly Occupied Molecular Orbital Catalysis:  The Carbo-Oxidation of Styrenes

Graham, T. H.; Jones, C. M.; Jui, N. T.; MacMillan, D. W. C.  J. Am. Chem. Soc. 2008130, 16494.

B. A Diastereoselective Intermolecular Heck Reaction of 1,3-Dioxepins

Nasveschuk, C. G.; Frein, J. D.; Jui, N. T.; Rovis, T. Org. Lett. 20079, 5099.

A. A Modular Approach to the Synthesis of 2,3,4-Trisubstituted Tetrahydrofurans

Nasveschuk, C. G.; Jui, N. T.; Rovis, T. Chem. Commun. 2006, 3119.

©2017 by Jui Research Group